This study evaluated sonrotoclax (an investigational BCL2 inhibitor) in patients with relapsed/refractory mantle cell lymphoma (R/R MCL) who had previously received anti-CD20-based therapy and at least one BTK inhibitor. Among 125 patients, sonrotoclax was well tolerated and demonstrated clinical activity, with a 53% response rate and a median response duration of nearly 16 months. Treatment-emergent adverse events (TEAEs) of any grade occurring in ≥20% of patients were blood-related, well tolerated, and manageable. TEAEs led to treatment discontinuation in 16 patients (13.9%) and death in 15 patients (13.0%). 42 deaths occurred but most were due to disease progression (n=29). These results support further investigation of sonrotoclax as a potential treatment option for patients with R/R MCL.

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