This study assessed BGB-16673, an investigational drug that degrades the BTK protein, in 60 patients with follicular lymphoma (FL) or marginal zone lymphoma (MZL) who had received multiple prior treatments. BGB-16673 was generally well tolerated. The most common TEAEs in either group were fatigue and neutropenia. TEAEs led to 1 treatment discontinuation in the FL group and 5 in the MZL group, and 1 death due to intracranial hemorrhage occurred in the MZL group. In 48 response-evaluable patients, the overall response rate was 41% (7/17) for FL, and 55% (17/31) for MZL, including among patients previously treated with BTK inhibitors. Some patients achieved complete responses, and many remained on treatment. These results support further study of BGB-16673 for these lymphoma subtypes.

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