Tag: Hematologic Malignancies
BeOne is advancing a hematologic malignancy pipeline consisting of novel oral small molecules and monoclonal antibodies. Among these are zanubrutinib, a next-generation Bruton’s tyrosine kinase inhibitor and BGB-11417, a BCL2 inhibitor, both for the treatment of various B-cell malignancies.
ASPEN (NCT03053440) is an open-label, randomized, Phase 3 study comparing the safety, efficacy and clinical benefit of zanubrutinib versus ibrutinib in activating MYD88 mutated (MYD88MUT) Waldenström’s macroglobulinemia (WM) patients. In an additional cohort, the efficacy and safety of zanubrutinib in MYD88 wild-type (MYD88WT) WM patients were evaluated.
Slide kit outlining the long-term follow-up of the ASPEN trial: Zanubrutinib vs. ibrutinib in patients with Waldenström’s macroglobulinemia (WM).



