Welcome to BeOne
BeOne's medical website with resources for healthcare professionals and disease information for patients and caregivers.
Back to all webinars
Diagnosis and prognosis in CLL/SLL
Paolo Ghia, Davide Rossi and Anna Schuh discuss diagnosis and prognosis in CLL, including a case study on the differential diagnosis of accelerated CLL and Richter’s syndrome and a debate on the clinical relevance of IGHV and TP53 as biomarkers.
Speakers
Update on CLL diagnosis and prognostic markers in clinical practice
Fast-forward to:
5th Edition of the WHO classification of hemopoietic and lymphoid malignancies
62f00a92ea53dd10d5f5d7af
Guideline recommendations: Mutation analysis
62f00af2e8cd6810e2873422
The PAST: deletions and/or mutations of TP53 on chromosome 17p
62f00b5ce8cd6810e2873428
Long term follow-up of the RESONATE trial
62f00be6e8cd6810e2873432
TP53 underlying disruption
62f00c4ef6524b10d688f865
CLL subclones: Sensitive detection tools are required
62f01493e8cd6810e2873442
SEQUOIA: Phase III randomized study of zanubrutinib vs. BR
62f01595ea53dd10d5f5d7d2
The IGHV locus: % homology; stereotypy; MRD targets
62f016a66c032b10dca547fa
Patients with mutated IGHV respond well to FCR
62f0173fea53dd10d5f5d7eb
Predictive value of MRD applies to immunochemotherapy
62f017daea53dd10d5f5d7f7
PFS and OS analyses based on PB MRD status at EoT in patients after 2 years of VenR
62f0186aea53dd10d5f5d802
Duration of treatment is defined by MRD measurement (FLAIR)
62f018d9f6524b10d688f894
MRD: What does the FDA say? What do the experts say?
62f019ceea53dd10d5f5d811
Using whole genome sequencing to further predict the outcome in CLL
62f01a9ae8cd6810e28734a3
Diagnosis and prognosis in CLL/SLL: Summary
62f01b0de8cd6810e28734b0
Differential diagnosis of accelerated CLL and Richter’s syndrome
Fast-forward to:
Case study: Progressive lymphoma
62f02b6e6c032b10dca5488f
Richter’s Syndrome: Definition and comparison of related and unrelated variants
62f033e26c032b10dca548a9
Differential diagnosis: Histologically aggressive CLL
62f034e4f6524b10d688f936
Pathological definitions of aggressive CLL and Richter syndrome
62f03569e8cd6810e287353f
Differential diagnosis of accelerated CLL and Richter’s syndrome: Summary
62f035e3ea53dd10d5f5d8d3
IGHV and TP53 are clinically relevant biomarkers
No entries
IGHV and TP53 are no longer clinically relevant biomarkers
No entries
Audience Q&A
Fast-forward to:
If a patient has Richter syndrome, and following initial treatment bone marrow shows 3% CLL cells, what is the best approach for treatment?
62f038e0f6524b10d688f99d
What is your opinion on novel PET radio tracers and PET MRI to distinguish CLL from accelerated CLL and Richter’s syndrome?
62f0391ce8cd6810e28735bb
Would earlier intervention reduce the number of cases of Richter’s syndrome?
62f03950f6524b10d688f9b1
Do we know if TP53 is a prognostic marker for zanubrutinib over acalabrutinib?
62f03985ea53dd10d5f5d946
Are there any biomarkers to help choose between targeted therapies for CLL?
62f039b3e8cd6810e28735c7
Would you use anti-CD20 therapy in a patient with NOTCH1 mutations?
62f039e7f6524b10d688f9ca
Is there any distinction between TP53 deletion and TP53 mutation, and is there any relevance of the type of allelic inactivation?
62f03a1df6524b10d688f9d0
Is there any role of repeating covalent BTK inhibitors in patients treated with venetoclax and already exposed to BTKis?
62f03a4fe8cd6810e28735de
Are there any distinguishing features between the efficacy or patient profiles of zanubrutinib or acalabrutinib?
62f03a7fe8cd6810e28735ec
Are there any new biomarkers to differentiate the CLL subtypes?
62f03ab16c032b10dca54996
Meeting summary
No entries