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Relapsed/refractory Waldenström’s macroglobulinemia: Key considerations for managing pre-treated patients
Christian Buske, Ramón García-Sanz, Véronique Leblond and Alessandra Tedeschi focus on treatment for patients with relapsed and refractory Waldenström’s macroglobulinemia, and look to the future of Waldenström’s macroglobulinemia treatment.
Speakers
First- and second-line treatment of a patient with WM
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What is the current approach for patients that are refractory to, or experience relapse, following first-line treatment?
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WM remains incurable and so it is vital to have optimal strategies for care of relapsed patients
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The influence of guidelines on treatment for relapsed WM
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The role of classical chemotherapy in relapsed WM
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The role of stem cell transplantation in relapsed WM
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Chemotherapy-free treatment options for relapsed WM
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Can next-generation BTK inhibitors provide benefits over ibrutinib for relapsed WM?
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What treatment options beyond BTK inhibitors are on the horizon?
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Summary and key challenges in relapsed WM treatment
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Case study - A patient with WM refractory to first-line treatment
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Case study - A patient with relapsed WM
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Cases study panel discussion
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What is your definition of a refractory WM patient?
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How do you tailor your treatment for relapsed/refractory WM according to mutational status?
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How do you tailor your treatment for relapsed/refractory WM according to rIPSS scores?
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For WM patients who relapse on ibrutinib, what is your next favoured treatment option?
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Open panel discussion
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Q&A
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How would you treat a patient who has developed intolerance to ibrutinib and rituximab?
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Should BTK inhibitors be used for younger patients before stem cell transplantation?
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How would you treat an 82-year old female who has failed three lines of treatment with DRC, ibrutinib and bendamustine, respectively?
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