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BGB-3111-215 Trial

Zanubrutinib (BTK inhibitor)

Hematology Small molecule Approved

Zanubrutinib is a second-generation Bruton’s tyrosine kinase inhibitor (BTKi) designed for selectivity, potency, and bioavailability.

BGB-3111-215 Trial

Sonrotoclax (BCL2 inhibitor)

Hematology Small molecule Approved

Sonrotoclax is a potent and selective BCL-2 inhibitor.

BGB-3111-215 Trial

BGB-16673 (BTK protein degrader)

Hematology Protein degrader Investigational

BGB-16673 is an investigational BTK-targeted protein degrader.

BGB-3111-215 Trial

Tislelizumab (PD-1 inhibitor)

Solid Tumors Monoclonal antibody Approved

Tislelizumab is a humanized IgG4 mAb that binds to PD-1 with high affinity and specificity.

BGB-3111-215 Trial

BGB-43395 (CDK4 inhibitor)

Solid Tumors Small molecule Investigational

BGB-43395 is an investigational CDK4 inhibitor developed to maximize sustained CDK4 pathway suppression while sparing CDK6

BGB-3111-215 Trial

BGB-B2033 (GPC3 x 4-1BB BsAb)

Solid Tumors Bispecific antibody Investigational

BGB-B2033 is an IgG-based bispecific antibody targeting GPC3 on tumor cells and the costimulatory receptor 4-1BB on T cells.

BGB-3111-215 Trial

BG-C9074 (B7-H4 ADC)

Solid Tumors ADC Investigational

BG-C9074 is an investigational ADC that targets B7-H4, with an innovative drug-linker design, a DAR of 6 (DAR6), and strong bystander effect

BGB-3111-215 Trial

BG-C477 (CEA ADC)

Solid Tumors ADC Investigational

BG-C477 is investigational antibody-drug conjugate (ADC) targeting CEA.

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